Inborn errors of mitochondrial fatty acid oxidation. Clin Rev Clin Lab Sci.
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Harris WS, Bulchandani D. Why do omega-3 fatty acids lower serum triglycerides? Curr Opin Lipidol. Czeczot H, Scibior D. Role of L-carnitine in metabolism, nutrition and therapy. Postepy Hig Med Dosw. Disorders of carnitine transport and the carnitine cycle. Carnitine supplementation and ketogenesis by small-for-date neonates on medium-and long-chain fatty acid formulae. Biol Neonate. FEBS letters. Antimyopathic effects of carnitine and nicotine. L-carnitine moderately improves the exercise tolerance in chronic stable angina.
J Assoc Physicians India. Influence of L-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass. Cardiovasc Res. Rizos I. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration. Am Heart J. The effects of L-carnitine treatment on left ventricular function and erythrocyte superoxide dismutase activity in patients with ischemic cardiomyopathy.
Eur J Heart Fail. Gaby AR. Nutritional treatments for acute myocardial infarction. Altern Med Rev. L-carnitine reduces plasma lipoprotein a levels in patients with hyper Lp a. Nutr Metab Cardiovasc Dis. The effect of L-carnitine on plasma lipoprotein a levels in hypercholesterolemic patients with type 2 diabetes mellitus.
Clin Ther. L-carnitine in the treatment of painful diabetic neuropathy and its effect on plasma beta-endorphin levels. Curr Ther Res Clin Exp. Kuratsune H. Chronic fatigue syndrome. Ryoikibetsu Shokogun Shirizu. Karanth J, Jeevaratnam K. Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity.
Indian J Exp Biol. L-carnitine administration reverses acute mental status changes in a chronic hemodialysis patient with hepatitis C infection. Clin Nephrol. L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIVinfected subjects treated with zidovudine and didanosine. Antioxid Redox Signal. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Metab. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial.
Fertil Steril. Effect of L-carnitine supplementation in hemodialysis patients. Beneficial effects of L-carnitine in dialysis patients with impaired left ventricular function: an observational study. Curr Med Res Opin.
A biochemical approach to nutrition /
Clinical effects of L-carnitine supplementation on apnea and growth in very low birth weight infants. Diagnostic approach and treatment of inherited mitochondrial fatty acid oxidation disorders. An Esp Pediatr. Stanley CA. Carnitine deficiency disorders in children. Carnitine biosynthesis in mammals. Biochem J.
Correlation of carnitine levels to methionine and lysine intake. Physiol Res.
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Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption. Br J Clin Pharmacol. Short-term carnitine supplementation does not augment LCPomega3 status of vegans and lacto-ovo-vegetarians. J Am Coll Nutr. Current issues regarding treatment of mitochondrial fatty acid oxidation disorders.
Kidney Blood Press Res. Involvement of L-carnitine in cellular metabolism: beyond Acyl-CoA transport. Mini Rev Med Chem. Disorders of muscle lipid metabolism: diagnostic and therapeutic challenges. Neuromuscul Disord. A diagnostic algorithm for metabolic myopathies. Curr Neurol Neurosci Rep.
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Disorders of the renal proximal tubule. Nephron Physiol. Karlic H, Lohninger A. Supplementation of L-carnitine in athletes: does it make sense? Long-term glycine propionyl-l-carnitine supplemention and paradoxical effects on repeated anaerobic sprint performance.
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J Int Soc Sports Nutr. L-carnitine supplementation: influence upon physiological function. Curr Sports Med Rep.
argo-karaganda.kz/scripts/wulehoco/3206.php L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women. L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise. Int J Vitam Nutr Res. Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet. Bipolar Disord.
Common dietary supplements for weight loss. Am Fam Physician. Services on Demand Article. English pdf Article in xml format Article references How to cite this article Automatic translation Send this article by e-mail. Keywords: Carnitine; Lipid metabolism; Weight loss. However, the homeostasis of carnitine is kept through very efficient mechanisms such as the ability of the human body to synthesize sufficient amounts of carnitine even under adverse dietetic management and a very efficient tubular re-absorption of carnitine under normal conditions.
The carnitine cycle depends basically on a good production and an adequate function of the enzymes carnitine palmiotyl transferase I, carnitine acylcarnitine translocase, and carnitine palmitoyl transferase II, whose production is not stimulated by carnitine. After hr growth of Synechococcus WH cells in iron-deplete medium a protein of Mj.
Repression of the protein's synthesis occurred after 24 hr growth in iron-replete medium.
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This protein was localized to both the internal membrane and the cell wall. By contrast, antibodies raised against the 36, Da polypeptide were able to detect the protein in internal membrane, cell wall and whole cell fractions of Synechococcus WH cells grown in both iron-replete and deplete medium. This suggests that the protein is expressed constitutively. Although partial characterization of the 36, Da polypeptide has, as yet, been unsuccessful, certain characteristics of the protein were reminiscent of those of TonB.
Antibodies raised against a synthetic peptide containing the x-proline dipeptide repeat of TonB were unable to detect a similar protein in Synechococcus WH However, Southern hybridization analysis using both the S. Once the blockage has been removed from the N-terminus of the 36 kDa protein the sequence should hopefully yield conclusive evidence as to the protein's function.
Sequestration of iron by Synechococcus WH cells was observed using flame atomic absorption spectroscopy on whole cell samples. Such sequestration suggests the presence of iron storage proteins. Western blot analysis and Mossbauer spectroscopy confirmed the presence of an iron storage protein namely bacterioferritin.